Naruto, chapter 365 page 08
(Sasuke: It must be the white snake's power..)
Karin: It could be Akarsuki or The Leaf but it doesn't really matter. The leaf might have info on Itachi, may be we should try to ambush them. What do you think, Sasuke?
Sasuke: If there are as many people as you said, then odds are it's The Leaf. Akatsuki only moves in two man teams.
Suigetsu: Ambushing them would be a waste of our time.
Sasuke: Agreed. We don't bother The Leaf.
Karin: What do we do, then?
Sasuke: Find Itachi. If we find him, then the worst case scenario is you three having to fight The Leaf Ninja.